Mutation

Pair I

AF

PF

Pair II

AF

PF

S(PF-AF)

1) Original pairs before mutation

O33599 N 117A

DN

2

2

NN

5

3

−2

O33599 H 210A

AH

3

2

HY

2

1

−2

O33599 D 214A

VD

3

1

DY

3

2

−3

O33599 H 291A

PH

1

0

HV

1

1

−1

O33599 H 293A

VH

1

1

HF

1

0

−1

P10547 H 279A

MH

2

0

HY

2

0

−4