N | % | N | % | ||||||||
No of pts treated with rhEpo | 268 | No of pts with serum Epo levels <500 mIU/ml | 217 | 93.5 | |||||||
No of pts evaluable for response | 232 | No of pts with serum Epo levels > 500 mIU/ml | 15 | 6.5 | |||||||
Complete response | 76 | 32.7 | No of pts with serum Epo levels < 200 mIU/ml | 145 | 62.5 | ||||||
Partial response | 36 | 15.5 | No of pts with serum Epo levels > 200 mIU/ml | 87 | 37.5 | ||||||
Overall response | 112 | 48.3 | No of pts with a RAI value < 21 | 171 | 73.7 | ||||||
No response | 120 | 51.7 | No of pts with a RAI value > 21 | 61 | 26.3 | ||||||
Ability of serum Epo levels to predict responders | 81/112 | 72.3 | |||||||||
Ability of RAI to predict responders | 107 /112 | 95.5 | |||||||||
Serum Epo levels | Responseto anemia index | ||||||||||
Type of response | <200 mIU/ml | % | >200 mIU/ml | % | RAI < 21 | % | p | RAI > 21 | % | p | |
CR | 58/145 | 40.0 | 18/87 | 20.7 | 73/172 | 42.4 | n.s. | 3/60 | 5.0 | <0.001 | |
PR | 23/145 | 15.9 | 13/87 | 14.9 | 34/172 | 19.8 | n.s. | 2/60 | 3.3 | <0.001 | |
OR | 81/145 | 55.9 | 31/87 | 35.6 | 107/172 | 62.2 | n.s. | 5/60 | 8.3 | <0.001 | |
NR | 64/145 | 44.1 | 56/87 | 74.4 | 65/172 | 37.8 | n.s. | 55/60 | 91.7 | <0.001 | |