Laboratory parameter

Initial evaluation

Cycle 2

Cycle 3

End

Paired Initial-Final variances (Var 95% CI) p

Haemoglobin (g/l)

36

33

32

32

6.9

(1.4 - 12.5)

0.017

115

(106 - 125.5)

112

(106 - 119)

111.5

(96 - 119)

110.5

(100.5 - 117.5)

Leukocytes

(×10⁹/l)

36

34

32

32

3.6

(2.8 - 4.3)

0.000

8.61

(7.72 - 0.42)

6.12

(4.74 - 8)

5.37

(4.71 - 6.6)

5.28

(4.41 - 6.6)

Neutrophils

(%)

36

34

32

32

20

(16 - 24.1)

0.000

72.6

(66.4 - 76.9)

58.5

(50.1 - 65.5)

54.8

(45.1 - 58.8)

51

(45.6 - 60.9)

Monocytes (%)

36

32

30

32

−2.3

(−3.7 - 0.9)

0.002

8.35

(7 - 10.1)

10.2

(7.5 - 12.4)

9.9

(8.6 - 11.6)

10.0

(8.4 - 13)

Lymphocytes (%)

36

34

31

32

−18.9

(−22.4 - 15.4)

0.000

16.5

(12.6 - 22.9)

28.8

(20.7 - 35.8)

34.6

(28.2 - 42.2)

37.05

(32.6 - 43.4)

Eosinophils (%)

36

27

26

28

1.2

(0.5 - 1.8)

0.000

1.4

(0.7 - 2.1)

0.8

(0.4 - 1.5)

0.65

(0.3 - 1.3)

0.45

(0.25 - 0.95)

Basophils (%)

33

26

26

27

−0.2

(−0.4 - 0)

0.034

0.3

(0.2 - 0.5)

0.45

(0.2 - 0.6)

0.4

(0.3 - 0.6)

0.5

(0.3 - 0.7)

Platelets (×10⁹/l)

36

34

32

32

232.5

(169.5 - 295.5)

0.000

453

(407.5 - 541.5)

320

(250 - 386)

267

(218.5 - 348)

243

(191 - 324.5)

ANC (×10⁹/l)

36

34

31

32

3.7

(3.1 - 4.3)

0.000

6.41

(5.28 - 7.77)

3.135

(2.54 - 4.92)

2.82

(2.06 - 3.84)

2.44

(2.01 - 3.325)