Study

Sample Size

Tumor Type

Duration of Follow-Up

Number (%) with Distant Metastasis at End of Follow-Up

Mean Time to Metastasis

Percentage with Metastasis-Free Survival

Predictors of Distant Metastasis after Treatment

Damato et al. 2005 [23]

349 patients

Choroidal melanoma

Median 3.1 years

2.5% died from metastasis at 2 years, 10.0% at 5 years, 14.1% at 8 years

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Longest basal tumor dimension, tumor height, extraocular tumor extension

Conway et al. 2006 [9]

21 patients

Extra large choroidal or ciliochoroidal melanomas

Median 28 months

3/21 (14.3%)

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Characteristics of patients with metastasis (no multivariate modeling performed): Mean age 80.7 years, maximum basal tumor diameter 21 - 24.4 mm

Mosci et al. 2012 [24]

72 patients

T3 and T4 choroidal melanomas

Mean 53.4 months

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72% at 5 years

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Tran et al. 2012 [25]

59 patients

Peripapillary choroidal melanoma

Median 63 months

15/59 (25.4%)

Median 38 months

82% at 5 years

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Schonfeld et al. 2014 [26]

18 patients

Choroidal melanoma in intermediate zone of fundus treated with proton beam therapy only

Median 77.2 months

1/18 patients (5.6%) died from metastasis

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