Study | Sample Size | Tumor Type | Duration of Follow-Up | Number (%) with Distant Metastasis at End of Follow-Up | Mean Time to Metastasis | Percentage with Metastasis-Free Survival | Predictors of Distant Metastasis after Treatment |
Sagoo et al. 2007 [10] | 37 patients | Circumpapillary choroidal melanoma | Mean 52 months, median 46 months | 1/37 (4%) | -- | -- | -- |
Sagoo et al. 2008 [11] | 141 patients | Juxtapapillary choroidal melanoma overhanging optic disc | Mean 56 months | 15 patients (13%) | -- | -- | -- |
Gunduz et al. 2010 [12] | 24 patients | Choroidal melanoma treated with ruthenium brachytherapy alone | -- | 2/24 (8.3%) | -- | -- | -- |
Verschueren et al. 2010 [13] | 430 patients | Choroidal melanoma | Median 50 months | 51/430 (11.9%) | 30.4 months (range 0 - 68.4 months) | 76.5% at 5 years, 69.1% at 10 years | -- |
Karlovits et al. 2011 [14] | 35 patients | Choroidal melanoma treated with iodine brachytherapy | Median 45 months | 5/35 (14.3%) | Median 58 months | -- | -- |
Newman et al. 2011 [15] | 50 patients | Subfoveal choroidal melanomas with ≥6 months of follow-up | Median 54 months | 2/50 (4%) | -- | -- | -- |
Sagoo et al. 2011 [22] | 650 patients | Juxtapapillary choroidal melanoma treated with plaque brachytherapy | -- | 11% at 5 years, 24% at 10 years | -- | -- | High intraocular pressure, greater tumor base |
Chang et al. 2012 [21] | 150 patients | Choroidal melanoma treated with iodine brachytherapy | Mean 21.5 months, median 17.3 months | 9/150 (6.0%) | -- | -- | -- |
Finger et al. 2012 [16] | 24 patients | Choroidal melanomas within 1.5 mm of optic disc treated with slotted radiotherapy | Mean 23 months | 0/24 (0.0%) | -- | -- | -- |
Berry et al. 2013 [17] | 82 patients | Medium sized choroidal melanomas | Median 46.8 months | 9/82 (10.9%) | 41.0 months (standard deviation [SD] = 34.7 months) | 89% at 60 months | -- |
Caminal et al. 2013 [18] | 54 patients | Choroidal melanoma treated with iodine brachytherapy | Mean 59.47 months | 11/54 (20.4%) | -- | 84.2% at 5 years | -- |
Semenova et al. 2013 [19] | 72 patients | Small choroidal melanomas | Mean 54 months | 0/72 (0.0%) | -- | -- | -- |
Semenova et al. 2014 [20] | 47 patients | T3 or T4 sized choroidal melanomas treated with palladium brachytherapy | Median 47 months | 15/47 (31.9%) | -- | -- | -- |