Study

Sample Size

Tumor Type

Duration of Follow-Up

Number (%) with Distant Metastasis at End of Follow-Up

Mean Time to Metastasis

Percentage with Metastasis-Free Survival

Predictors of Distant Metastasis after Treatment

Sagoo et al. 2007 [10]

37 patients

Circumpapillary choroidal melanoma

Mean 52 months, median 46 months

1/37 (4%)

--

--

--

Sagoo et al. 2008 [11]

141 patients

Juxtapapillary choroidal melanoma overhanging optic disc

Mean 56 months

15 patients (13%)

--

--

--

Gunduz et al. 2010 [12]

24 patients

Choroidal melanoma treated with ruthenium brachytherapy alone

--

2/24 (8.3%)

--

--

--

Verschueren et al. 2010 [13]

430 patients

Choroidal melanoma

Median 50 months

51/430 (11.9%)

30.4 months (range 0 - 68.4 months)

76.5% at 5 years, 69.1% at 10 years

--

Karlovits et al. 2011 [14]

35 patients

Choroidal melanoma treated with iodine brachytherapy

Median 45 months

5/35 (14.3%)

Median 58 months

--

--

Newman et al. 2011 [15]

50 patients

Subfoveal choroidal melanomas with ≥6 months of follow-up

Median 54 months

2/50 (4%)

--

--

--

Sagoo et al. 2011 [22]

650 patients

Juxtapapillary choroidal melanoma treated with plaque brachytherapy

--

11% at 5 years, 24% at 10 years

--

--

High intraocular pressure, greater tumor base

Chang et al. 2012 [21]

150 patients

Choroidal melanoma treated with iodine brachytherapy

Mean 21.5 months, median 17.3 months

9/150 (6.0%)

--

--

--

Finger et al. 2012 [16]

24 patients

Choroidal melanomas within 1.5 mm of optic disc treated with slotted radiotherapy

Mean 23 months

0/24 (0.0%)

--

--

--

Berry et al. 2013 [17]

82 patients

Medium sized choroidal melanomas

Median 46.8 months

9/82 (10.9%)

41.0 months (standard deviation [SD] = 34.7 months)

89% at 60 months

--

Caminal et al. 2013 [18]

54 patients

Choroidal melanoma treated with iodine brachytherapy

Mean 59.47 months

11/54 (20.4%)

--

84.2% at 5 years

--

Semenova et al. 2013 [19]

72 patients

Small choroidal melanomas

Mean 54 months

0/72 (0.0%)

--

--

--

Semenova et al. 2014 [20]

47 patients

T3 or T4 sized choroidal melanomas treated with palladium brachytherapy

Median 47 months

15/47 (31.9%)

--

--

--