Factor

H-VFA group

L-VFA group

p value

(Before TACE)

n = 58

n = 38

Age (years)

71

(41 - 87)

71

(55 - 83)

0.784

Sex (male/female)

37/21

24/14

0.950§

Height (cm)

160.0 ± 9.8

(138.5 - 179.0)

160.2 ± 7.6

(147.7 - 176.9)

0.452*

Body weight (kg)

63.1

(40.2 - 93.6)

56.8

(37.0 - 73.6)

0.003

BMI (kg/m2)

24.4 ± 2.6

(20.1 - 30.2)

22.2 ± 2.8

(15.6 - 28.0)

0.000*

HBs Ag (+/−)

7/51

5/33

1.000

HCV Ab (+/−)

36/22

30/8

0.081§

Alcohol (over 20 g/day)(+/−)

20/38

11/27

0.571§

Child's score (5, 6, 7, 8, 9)

6 (5 - 9)

7 (5 - 9)

0.390

MELD score

7.0 (6.0 - 12.3)

7.3 (6.0 - 20.7)

0.227

TNM stage of HCC (I, II, III, IVa, IVb)

5/11/37/3/2

3/20/15/0/0

0.003*

Past treatment frequency of TACE (times)

1 (0 - 11)

1 (0 - 10)

0.283

Past treatments other than TACE (+/−)

24/34

16/22

0.944§

Subcutaneous and intermuscular fat area (cm2/m2)

59.8 ± 18.1 (33.6 - 97.8)

44.4 ± 27.1 (2.8 - 101.4)

0.001*

Skeletal muscle area (cm2/m2)

43.0 ± 8.7 (20.5 - 70.8)

41.8 ± 7.2 (21.7 - 57.6)

0.232*

Sarcopenia (+/−)

39/19

26/12

0.904§

PT (%)

80.3

(58.5 - 100.0)

82.4

(57.6 - 100.0)

0.827

AST (IU/L)

48

(19 - 165)

49

(18 - 141)

0.412

ALT (IU/L)

36

(11 - 111)

37

(13 - 130)

0.875

γ-GTP (IU/L)

51

(20 - 857)

47

(10 - 1188)

0.436

T-Bil (mg/dL)

0.8

(0.3 - 2.5)

1.0

(0.3 - 2.5)

0.044

ChE (IU/L)

161

(81 - 348)

145

(47 - 327)

0.123

Alb (g/dL)

3.6

(2.4 - 4.8)

3.4

(2.4 - 4.5)

0.346

Prealbumin (mg/dL)

11.5

(4.2 - 28.2)

10.9

(4.5 - 33.1)

0.479

BTR

3.9

(1.5 - 7.4)

4.0

(1.9 - 8.0)

0.691

CRP

0.1

(0.1 - 6.1)

0.1

(0.1 - 2.9)

0.401

Crn

0.77

(0.44 - 1.93)

0.72

(0.45 - 4.91)

0.514

FPG (mg/dL)

104

(71 - 234)

98

(74 - 351)

0.142

IRI (µU/mL)

11

(4 - 84)

11

(1 - 40)

0.280

HOMA-IR

2.8

(0.81 - 43.30)

2.64

(0.19 - 20.80)

0.310

HbA1c (%)

5.6

(4.4 - 8.2)

5.1

(4.3 - 10.2)

0.017

ICG test retention rate at 15 min (%)

25.4

(5.5 - 59.5)

23.4

(3.5 - 75.6)

0.919

Type 4 collagen 7S (ng/mL)

6.5

(3.0 - 14.0)

7.8

(3.6 - 16.0)

0.132

HA (ng/mL)

229

(12.4 - 1483.6)

332.9

(48.1 - 1237.8)

0.074

AFP (ng/mL)

36

(2 - 94260)

26

(5 - 14183)

0.694

DCP

250

(14 - 688500)

93

(14 - 12749)

0.076