Grade 3/4 AE

27.9 (12.9, 60.3)

ECOG PS (reference category = 0)

1

≥2

1.2 (0.8, 1.9)

4.5 (1.9, 10.3)

Primary site at advanced melanoma diagnosis (reference category = cutaneous)

Uveal

Mucosal

1.6 (0.5, 5.4)

2.7 (0.5, 13.9)

Brain metastases at advanced melanoma diagnosis (reference category = no brain metastases)

1.8 (0.8, 3.9)

Stage M1 at advanced diagnosis (reference category = Stage M0)

1.5 (0.8, 2.9)