| animal model | Gene and inciting factors | Feeding patterns | Time | age/weight |
| Mice |
|
|
|
|
| C57Bl/6J mice [41] | LDLr-/- | HF/HC (59% of calories are high in palmitic acid, no cholesterol) | 2 - 4 months | 20 to 25 g |
| C57BL/6 background mice [39] | LDLr-/-ApoB100/100 | normal chow | mean 20.1 months | 17 to 22 months |
| C57BL/6 background mice [135] | LDLr (-/-)/ApoB (100/100)/IGF-II | diet high in fat (55%), sucrose (28%) and cholesterol (0.2%) | 6 months | 12 weeks |
| C57BL/6Jbackground mice [38] | ApoE-/-; age | normal chow | ≥43 weeks | ≥43 weeks |
| C57BL/6 background mice [136] | ApoE-/- | 0.2% high cholesterol diet | 24 weeks | 6 - 8 weeks |
| C57BL/6Jbackground mice [137] | apoE-/- | atherogenic diet (42% milk fat,0.2% total cholesterol) | 20 weeks | 30 weeks |
| C57BL/6Jbackground mice [138] | apoE-/- | an atherogenic diet (15% fat,1.25% cholesterol) | 8 weeks | 8 weeks |
| C57BL/6Jbackground mice [139] | Lrp5-/-/ApoE-/- | a 0.2% cholesterol (w/w) diet | 23 weeks | 6 - 8 weeks |
| Adult waved-2 mice [140] | C57BL/6JEgfrWa2/Wa2 | 65.7% lipids, 19.5% carbohydrate, and 4.5% cholesterol, Subcutaneous injection three times weekly 16,000 IU/g vita-minD3 | 6 or 9 months | 1.5 months of age |
| Rabbit |
|
|
|
|
| Normal New Zealand White rabbits [141] | no | 2% cholesterol (w/w) added to soybean oil (10% w/w) | 29 days | 2.5 kg, 8 weeks old |
| Male New Zealand White rabbits [31] | no | diet supplemented with 1.0% (wt/wt) cholesterol | 8 weeks | 2.5 to 3.0 kg |
| male New Zealand White rabbits [49] | no | fed with 0.5% cholesterol enriched chow plus 50,000 IU/day vitamin D2 in drinking water. | 12 weeks | 2 to 2.5 kg |
| male New Zealand white rabbits [142] | no | fed 0.5% cholesterol-enriched chow plus 25,000 IU/day vitamin D2 | 12 weeks | 2.5 to 3.0 kg |
| male New Zealand White rabbits [143] | no | Place on vitamin D-enriched atherogenic diet (purified rabbit chow supple-mented with 0.5% cholesterol and 10,000 IU/day vitamin D) | 3 weeks + 4 weeks | 3 months/3.7 ± 0.2 kg |
| Swine |
|
|
|
|
| male swine [17] | no | an isocaloric diet high in fat (12%) and cholesterol (1.5%) | 2 week or 6 months | 6 months |
| Gene + HCVD diet |
|
|
|
|
| Notch1 and RBPJk targeted mutant mice [144] | Notch1 and RBPJk targeted mutant | The HCVD diet | 16 weeks | 8 - 10 weeks |