Exposure to:

Number of cells ×10⁶

NL/АМ

count ratio

total

neutrophil

leukocytes (NL)

alveolar macrophages (АМ)

24 hours after the intratracheal instillation of NiO-NPs and Mn₃O₄ + NPs

Me-NPs

9.6 ± 1.6*

7.17 ± 1.24*

2.3 ± 0.43

3.44 ± 0.62*

Me-NPs after 4 weeks BPC administration

5.7 ± 1.49

3.36 ± 1.38*⁺

2.3 ± 0.29

1.46 ± 0.54*⁺

Water after 4 weeks BPC administration

3.8 ± 0.75

0.67 ± 0.21

3.09 ± 0.64

0.23 ± 0.07

Water (control)

3.8 ± 0.9

0.34 ± 0.12

3.4 ± 0.86

0.12 ± 0.05

24 hours after the intratracheal instillation of PbO-NPs + CuO-NPs + ZnO-NPs

Me-NPs

7.93 ± 0.62*

5.86 ± 1.52*

2.07 ± 0.21

2.83 ± 0.77

Me-NPs after 4 weeks BPC administration

3.30 ± 0.53*⁺

1.47 ± 0.36⁺*

1.82 ± 0.40

1.11 ± 0.30⁺

Water after 4 weeks BPC administration

2.18 ± 0.41

1.20 ± 0.35*

0.98 ± 0.25

1.59 ± 0.55*

Water (control)

1.40 ± 0.07

0.094 ± 0.029

1.30 ± 0.07

0.075 ± 0.024