Patient Cohort | P value for comparisons with general population | ||||||
All Patients N = 121 | All Migraine N = 83 | All Migraine w/out aura N = 80 | General Population | All patients | Migraine patients | Migraine w/out aura patients | |
ApoE (CVD risk) | <0.0001 | <0.0001 | <0.0001 | ||||
Low | 82 (67.8) | 57 (68.7) | 54 (67.5) | 7342 (83.8) | <0.0001 | 0.0002 | <0.0001 |
Intermediate | 11 (9.1) | 10 (12.1) | 10 (12.5) | 1424 (16.2) | 0.0330 | 0.2984 | 0.3618 |
High | 28 (23.1) | 16 (19.3) | 16 (20.0) | 0 (0) | <0.0001 | <0.0001 | <0.0001 |
Factor II | 0.6055 | 1.00 | 1.00 | ||||
Detected heterozygote | 2 (1.7) | 2 (2.4) | 2 (2.5) | 810 (3.2) | 0.4439 | 1.00 | 1.00 |
Detected homozygote | 0 (0) | 0 (0) | 0 (0) | 10 (0.04) | 1.00 | 1.00 | 1.00 |
Not detected | 119 (98.3) | 81 (97.6) | 78 (97.5) | 24,313 (96.7) | 0.4439 | 1.00 | 1.00 |
Factor V Leiden | 0.0066 | 0.0004 | 0.0003 | ||||
Detected heterozygote | 9 (7.4) | 7 (8.4) | 7 (8.7) | 1270 (5.1) | 0.2325 | 0.1995 | 0.1213 |
Detected homozygous mutant | 1 (0.8) | 1 (1.2) | 1 (1.3) | 19 (0.08) | 0.0916 | 0.0638 | 0.0616 |
Not detected | 111 (91.7) | 75 (90.4) | 72 (90.0) | 23,847 (94.9) | 0.1192 | 0.0757 | 0.0676 |
MTHFR | 0.0063 | 0.0026 | 0.0029 | ||||
Detected heterozygote | 26 (21.5) | 18 (21.7) | 18 (22.5) | 5522 (22.0) | 0.8988 | 0.9508 | 0.9086 |
Detected homozygous mutant | 18 (14.9) | 14 (16.9) | 13 (16.3) | 3127 (12.4) | 0.4181 | 0.2226 | 0.3028 |
Intermediate sensitivity | 1 (0.8) | 1 (1.2) | 1 (1.2) | 0 (0) | 0.0048 | 0.0033 | 0.0032 |
Not detected | 76 (62.8) | 50 (60.2) | 48 (60.0) | 16,488 (65.6) | 0.5204 | 0.3056 | 0.2932 |