| Inflammatory mediators | Signaling mediators | Proteases | |
| TNF | NFκB | MMP-1 | |
| IL-1β | ERK1/2 | MMP-3 | |
| IL-6 | p38 | MMP-9 | |
| IL-8 | JNK | MMP-13 | |
| IL-15 | PKCδ | ADAMTS-4 | |
| IL-17 | TLRs | ADAMTS-5 | |
| IL-21 | β-cantenin | TACE | |
| PGE2 | Gli1 |
| |
| Substance P | Ptch |
| |
| NGF | HHIP |
| |
| EGF | HIF-2α |
| |
| VEGF | Inos |
| |
| FGF-2 | RUNX2 |
| |