Absorption

・ Max plasma concentration in 9 - 14h

Distribution

・ Bioavalability ≈ 55%

・ Volume of distribution 20 - 25 L for a 100 kg person

・ Plasma protein binding (>98%)

Metabolism

・ Similar to that of large proteins

・ In vitro studies suggest metabolism by DPP-4 and neutral endopeptidase

Excretion

・ No specific organ is major route of elimination (drug is metabolized)

o Some metabolites excreted in feces (5%) and urine (6%)

・ Mean apparent clearance 0.9 - 1.4 L/h

・ Half-life ≈13 h