Absorption | ・ Max plasma concentration in 9 - 14h |
Distribution | ・ Bioavalability ≈ 55% ・ Volume of distribution 20 - 25 L for a 100 kg person ・ Plasma protein binding (>98%) |
Metabolism | ・ Similar to that of large proteins ・ In vitro studies suggest metabolism by DPP-4 and neutral endopeptidase |
Excretion | ・ No specific organ is major route of elimination (drug is metabolized) o Some metabolites excreted in feces (5%) and urine (6%) ・ Mean apparent clearance 0.9 - 1.4 L/h ・ Half-life ≈13 h |