NCC (2007-2010, P)

Phase I dose escalation study, three dose levels, exclusion criteria = tumors in contact with gastrointestinal tissue

27

60 Gy in 20 f (8 pts) (dose level 1) 66 Gy in 22 f (7 pts) (dose level 2) 72 Gy in 24 f (12 pts) (dose level 3)

31 m (5.2 - 63.4)

100%, 86% and 100% in dose levels 1, 2 and 3 respectively CR = 62.5%, 57%, 1% and 100% in dose levels 1, 2 and 3, respectively (P = 0.03)

OS at 3 y 25%, 66.7% and 73.3% in dose levels 1, 2 and 3 respectively (P = NS)

No ≥ G3 acute and late toxicities