Time after the formalin injection, min

Average score

20 min

25 min

30 min

35 min

40 min

45 min

50 min

55 min

60 min

Control, saline

3.0 (2.0 ÷ 3.0)

2.5 (2.0 ÷ 3.0)

2.0 (2.0 ÷ 2.0)

2.0 (2.0 ÷ 2.0)

2.0 (2.0 ÷ 2.0)

2.0 (2.0 ÷ 2.0)

2.0 (2.0 ÷ 2.0)

2.0 (1.0 ÷ 2.0)

2.0 (0.5 ÷ 2.0)

18.5 (17.5 ÷ 19.5)

Hemantane, 20 mg/kg

1.0 (0.0 ÷ 2.0)*

2.0 (2.0 ÷ 2.0)

2.0 (2.0 ÷ 2.0)

2.0 (2.0 ÷ 2.0)

2.0 (2.0 ÷ 2.0)

1.5 (1.0 ÷ 2.0)

2.0 (1.0 ÷ 2.0)

1.0 (1.0 ÷ 2.0)

0.5 (0.0 ÷ 2.0)

13.5 (12.0 ÷ 16.0)*

Amantadine, 20 mg/kg

1.5 (1.0 ÷ 2.0)

2.0 (1.5 ÷ 2.0)

2.0 (2.0 ÷ 2.5)

2.0 (1.0 ÷ 2.0)

2.0 (1.5 ÷ 2.0)

1.0 (1.0 ÷ 2.0)

1.5 (1.0 ÷ 2.0)

1.5 (1.0 ÷ 2.0)

2.0 (1.0 ÷ 2.0)

15.5 (12.5 ÷ 17.5)

Diclofenac sodium, 10 mg/kg

1.0 (1.0 ÷ 1.0)*

2.0 (1.0 ÷ 2.0)*

2.0 (2.0 ÷ 2.0)

2.0 (2.0 ÷ 2.0)

1.5 (1.0 ÷ 2.0)

1.0 (1.0 ÷ 2.0)

1.0 (1.0 ÷ 2.0)

1.0 (0.0 ÷ 2.0)

1.0 (0.0 ÷ 2.0)

13.0 (8.0 ÷ 17.0)*