| Time after the formalin injection, min | Average score | ||||||||
20 min | 25 min | 30 min | 35 min | 40 min | 45 min | 50 min | 55 min | 60 min | ||
Control, saline | 3.0 (2.0 ÷ 3.0) | 2.5 (2.0 ÷ 3.0) | 2.0 (2.0 ÷ 2.0) | 2.0 (2.0 ÷ 2.0) | 2.0 (2.0 ÷ 2.0) | 2.0 (2.0 ÷ 2.0) | 2.0 (2.0 ÷ 2.0) | 2.0 (1.0 ÷ 2.0) | 2.0 (0.5 ÷ 2.0) | 18.5 (17.5 ÷ 19.5) |
Hemantane, 20 mg/kg | 1.0 (0.0 ÷ 2.0)* | 2.0 (2.0 ÷ 2.0) | 2.0 (2.0 ÷ 2.0) | 2.0 (2.0 ÷ 2.0) | 2.0 (2.0 ÷ 2.0) | 1.5 (1.0 ÷ 2.0) | 2.0 (1.0 ÷ 2.0) | 1.0 (1.0 ÷ 2.0) | 0.5 (0.0 ÷ 2.0) | 13.5 (12.0 ÷ 16.0)* |
Amantadine, 20 mg/kg | 1.5 (1.0 ÷ 2.0) | 2.0 (1.5 ÷ 2.0) | 2.0 (2.0 ÷ 2.5) | 2.0 (1.0 ÷ 2.0) | 2.0 (1.5 ÷ 2.0) | 1.0 (1.0 ÷ 2.0) | 1.5 (1.0 ÷ 2.0) | 1.5 (1.0 ÷ 2.0) | 2.0 (1.0 ÷ 2.0) | 15.5 (12.5 ÷ 17.5) |
Diclofenac sodium, 10 mg/kg | 1.0 (1.0 ÷ 1.0)* | 2.0 (1.0 ÷ 2.0)* | 2.0 (2.0 ÷ 2.0) | 2.0 (2.0 ÷ 2.0) | 1.5 (1.0 ÷ 2.0) | 1.0 (1.0 ÷ 2.0) | 1.0 (1.0 ÷ 2.0) | 1.0 (0.0 ÷ 2.0) | 1.0 (0.0 ÷ 2.0) | 13.0 (8.0 ÷ 17.0)* |