|
| Objective described | Main outcomes described | Patient characteristics described | Interventions stated | *Principal confounders described | Main findings described | Estimates of random variability given | Adverse events reported | Loss to follow-up described | Exact p-values reported | Subjects invited represent population | Subjects participated represent population | Treatment location representative of source population | Subject blinding | Assessor blinding | “Data dredging” made clear | Analysis adjusted for different lengths of follow-up | Appropriate statistical tests used | Compliance with intervention(s) reliable | Valid & reliable outcome measures | Recruitment from same population | Recruitment during same time period | Subjects randomized | Concealed, random group assignment | Adjustment for confounding in analyses | Losses to follow-up taken into account | Sufficient power | Total scores |
| Allcock et al. (2006) | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 13 |
| Idiaquez et al. (2007) | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 13 |
| Jones et al. (2014) | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 14 |
| Kim et al. (2012) | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 14 |
| Nobili et al. (2011) | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 14 |
| Peralta et al. (2007) | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12 |
| Pileri et al. (2013) | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 14 |