MP formulation No. | PLGA type | Co-grinding time (min) | TDC (%) | EDC (%) | LE (%) | Particle size (μm) |
1 | PLGA7505 | 10 | 9.1 | 9.4 ± 0.0 | 103.2 ± 0.4 | 32.9 ± 18.5 |
2 | PLGA7510 | 10 | 9.1 | 9.1 ± 0.0 | 99.7 ± 0.0 | 30.4 ± 19.1 |
3 | PLGA7505 | 10 | 16.7 | 17.1 ± 0.1 | 102.2 ± 0.5 | 32.3 ± 19.6 |
4 | PLGA7510 | 10 | 16.7 | 17.1 ± 0.2 | 102.3 ± 1.0 | 29.2 ± 20.4 |
5 | PLGA7505 | 60 | 9.1 | 9.5 ± 0.0 | 104.2 ± 0.5 | 20.5 ± 10.1 |
6 | PLGA7505 | 60 | 16.7 | 17.3 ± 0.1 | 103.8 ± 0.6 | 25.2 ± 16.6 |