Formulation

Drug dissolved (μg/ml)

5 min

15 min

30 min

60 min

90 min

120 min

FF

8.8 ± 0.4

12.6 ± 0.6

13.3 ± 0.1

15.0 ± 0.1

15.0 ± 0.1

15.0 ± 0.3

SDF1

21.1 ± 0.1*

23.9 ± 0.1*

24.9 ± 0.1*

26.8 ± 0.3*

27.8 ± 0.3*

29.7 ± 0.2*

SDF2

16.3 ± 0.1*

18.2 ± 0.2*

19.2 ± 0.1*

21.1 ± 0.2*

21.0 ± 0.1*

22.0 ± 0.1*

SDF3

16.3 ± 0.2*

19.2 ± 0.2*

19.2 ± 0.1*

21.1 ± 0.2*

21.1 ± 0.3*

21.9 ± 0.3*

SDF4

10.3 ± 0.3*

12.9 ± 0.3*

14.1 ± 0.6*

18.2 ± 0.3*

20.7 ± 0.2*

23.3 ± 0.3*

SDF5

14.2 ± 0.2*

14.6 ± 0.3*

15.1 ± 0.2*

17.3 ± 0.3*

23.3 ± 0.2*

24.8 ± 0.1*

SDF6

15.9 ± 0.1*

18.0 ± 0.2*

18.1 ± 0.1*

23.2 ± 0.2*

23.8 ± 0.1*

26.4 ± 0.2*

SDF7

29.6 ± 0.1*^Ϯ↑

30.7 ± 0.2*^Ϯ↑

34.8 ± 0.2*^Ϯ↑

35.9 ± 0.1*^Ϯ↑

38.0 ± 0.2*^Ϯ↑

38.3 ± 0.5*^Ϯ↑