Patient characteristics | Propofol (n = 43) | Etomidate (n = 55) | p-value |
Age, yrs1 | 57 ± 18.2 | 63 ± 17.2 | 0.12 |
Male sex, n (%) | 19 (44.2) | 24 (43.6) | 0.31 |
Height (cm)1 | 169.2 ± 26.9 | 144.3 ± 61.3 | 0.15 |
Weight (kg)1 | 74.8 ± 18.6 | 74.1 ± 29.5 | 0.57 |
APACHE II2 | 22 (15 - 26) | 21 (17 - 25) | 0.23 |
Comorbidities |
|
|
|
Hypertension | 27 (62.7) | 42 (76.3) | 0.18 |
Diabetes | 11 (25.5) | 19 (34.5) | 0.38 |
Malignancy | 13 (30.2) | 17 (30.9) | 0.99 |
COPD | 2 (4.6) | 6 (10.9) | 0.45 |
CHF | 5 (11.6) | 9 (16.3) | 0.57 |
Tobacco smoker | 11 (25.5) | 6 (10.9) | 0.06 |
Abnormal LFTs | 7 (16.3) | 11 (20.0) | 0.79 |
Cirrhosis | 4 (9.3) | 7 (62.7) | 0.75 |
ESRD | 3 (6.9) | 6 (12.7) | 0.72 |
Prior intubations | 1 (2.3) | 0 (0) | 0.43 |
Baseline laboratory tests |
|
|
|
SCr | 1.1 ± 0.5 | 2.3 ± 0.6 | 0.25 |
BUN | 25.1 ± 17.3 | 26.7 ± 18.9 | 0.64 |
WBC | 12.2 ± 5.6 | 11.9 ± 5.1 | 0.84 |
pH | 7.3 ± 0.1 | 7.3 ± 0.2 | 0.27 |
Baseline vital signs |
|
|
|
Heart rate | 102.9 ± 32.9 | 93.9 ± 25.5 | 0.08 |
Respiratory rate | 20.7 ± 7.5 | 21.1 ± 6.8 | 0.10 |
SBP (mmHg) | 139.2 ± 29.7 | 136.8 ± 33.6 | 0.71 |
DBP (mmHg) | 74.4 ± 20.5 | 71.7 ± 18.4 | 0.50 |
MAP | 95.9 ± 22.2 | 92.9 ± 21.0 | 0.51 |
Temperature (F) | 97.9 ± 2.0 | 97.7 ± 1.7 | 0.10 |