| Authors | Year | Proteomic technique | Tissue source | n | Biomarkers identified | Validation |
| Chi et al. | 2009 | LC-MS/MS, LC-ESI-MALDI Tandem MS, MALDI-TOF | Oral cavity SCC cell lines―validated in laryngeal SCC | 18 | áUCRP | Not in a separate population |
| Dowling et al. | 2008 | LC-MS, 2DE | Laryngeal SCC, salivary samples | 4 | áS100 calcium binding protein A9, ábeta fibrin, átransferrin, áimmunoglobulin heavy chain constant region gamma, ácofilin, âtransthyretin | S100 calcium binding protein validated by immunoblot analysis |
| Karahatay et al. | 2007 | LC/MS | Laryngeal SCC tissue | 10 | áC16-, âC18-, áC24-, áC24:1-ceramides | Nil |
| Parolini et al. | 1996 | SDS-PAGE, ELISA | Laryngeal SCC tissue frozen or fixed in paraformaldehyde | 70 | áuPA | uPA and mRNA expression using ISH |
| Sepiashvili et al. | 2012 | MS, 2DE | Laryngeal SCC cell lines | 2 | áPLAU, áIGFBP7, áMMP14 and áTHBS1 | Validated using IHC and ELISA in 56 laryngeal SCC |
| Sewell et al. | 2007 | MALDI-TOF, MS, 2D-DIGE | Laryngeal SCC frozen tissue | 2 | âstratifin, âS100 calcium-binding protein A9, âp21-ARC, âstathmin, and áenolase, áMAGE D3, átransferrin, áalbumin, átumor-associated calcium signal transducer | Nil |
| Yoshizaki et al. | 1997 | SDS-PAGE | Laryngeal SCC tissue fixed in formalin | 9 | áMT1-MMP | Nil |