Substance

Subject

Benefit

Adverse Effects Observed

Drawbacks

AAV9-ADAR2 injection

Mice

・ Rescue of motor neurons from death

・ Neuron regeneration

N/A

・ Little known mechanism

Riluzole

Humans

・ Prolong overall survival?/delay disease progression

・ Diarrhea

・ Dizziness

・ Fatigue

・ Nausea

Stem cells (Human Umbilical Cord Blood Cells, HUCBCs)

Mice

・ Low immunogenicity

・ Retard disease progression

・ Prolong survival

・ Improve motor function and neuromuscular transmission

・ attenuate astrogliosis

N/A

・ Ethical issue with use