| Year | Application Per Day | Number of Days | Elimination after trial | Recolonization | Reference |
| 1986 | 4× per Day | 5 Days | 100% | 16% at 3 weeks | [67] |
| 1988 | 3× per Day | 5 Days | 100% | 6% at 2 weeks | [76] |
| 1989 | 3× per Day | 5 Days | 97% | 40% at 2 weeks | [77] |
| 1991 | 2× - 3× per day | 3-8 days | 97% | Unknown | [79] |
| 1992 | 2× per day | 5 days | 91% | Unknown | [80] |
| 1992 | 2× per day | 5 days | 74% | 22% at 4 weeks | [81] |
| 1994 | 2× per day | 5 days | 91% | 26% at 4 weeks | [82] |
| 1995 | 2× per day | 5 days | 86.7% | 43% at 4 weeks | [83] |
| 2002 | 2× per day | 5 days | 82% | Unknown | [85] |
| 2002 | 2× per day | 5 days | 83% | Unknown | [86] |
| 2006 | 2× per day | 5 days | 81% | Unknown | [87] |