| Pathogen isolate | Combination therapy | Adult dosage |
| Cefoperazone/Sulbactam | Cefoperazone:Sulbactam ratio = 1:1 | |
| Acinetobacter baumanii |
| Mild infection: 1 - 2 gr/IV every 12 hours |
| Pseudomonas aeruginosa | plus | Severe infection: max 4 gr/IV/day every 12 hours |
| Klebsiella pneumoniae | Amikacin | CrCl < 30 ml/min: Sulbactam 2 gr/IV/day |
| CrCl < 15 ml/min: Sulbactam 1 gr/IV/day | ||
| 15 - 20 mg/kg/IV every 24 day | ||
| Staphylococcus spp. | Vancomycin | 20 - 45 mg/kg/IV every 6 - 12 day |
| CrCl < 30 ml/min: 10 - 15 mg/kg every 24 jam | ||
| CrCl < 15 ml/min: 10 - 15 mg/kg every 48 jam |