Matrix

Time (min)

Solvent A (%)

Solvent B (%)

Flow rate (mL/min)

Plasma

Initial

50

50

0.2

3.00

10

90

0.2

6.00

10

90

0.2

6.01

50

50

0.2

12.00

50

50

0.2

Lung homogenate

Initial

70

30

0.2

3.00

10

90

0.2

8.00

10

90

0.2

8.10

70

30

0.2

14.00

70

30

0.2