Drug name

Target

Type of antibody

Indications

Nivolumab

PD-1

IgG4

Metastatic melanoma, adjuvant treatment of melanoma, metastatic non-small cell lung cancer, classical Hodgkin’s lymphoma, renal cell carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, urethral cancer, bladder cancer, mismatch repair defect colon cancer

Pembrolizumab

PD-1

IgG4

Highly microsatellite unstable tumors, melanoma, non-small cell lung cancer, classic Hodgkin’s lymphoma, head and neck squamous cell carcinoma, urethral cancer, gastric cancer

Atezolizumab

PD-L1

IgG1

Advanced bladder cancer, metastatic non-small cell lung cancer, locally advanced or metastatic urethral cancer

Durvalumab

PD-L1

IgG1

Locally advanced or metastatic urethral cancer

Avelumab

PD-L1

IgG1

Locally advanced or metastatic urethral cancer, metastatic Merkel cell carcinoma in adolescents and adults