Patient 1

Patient 2

Solid Organ Transplant (Indication)

Liver (HCV)

Heart (Non-ischemic)

Age at transplant, y

56

70

Immunosuppression regimen

Tacrolimus, MMF

Tacrolimus, MMF, prednisone

Sex

Male

Male

Body mass index, kg/m2

27.9

30.2

Voriconazole exposure time leading to periostitis

61d (8.7 wks)

257d (36.7 wks)

Estimated total voriconazole dose until onset, g

48.4

205

Mean tacrolimus trough level, ng/mL

5.3

8.9

Median tacrolimus trough level, ng/mL

4.8

8.7

Laboratory values at voriconazole initiation

Glomerular filtration rate, mL/min

58

>60

Alanine transferase, U/L^?/sup>

13

14

Alkaline phosphatase, U/L^¥

107

75

Parathyroid hormone, pg/ml^Ω

13

N/A

Laboratory values during voriconazole treatment

Glomerular filtration rate, mL/min

~20*

>60

Alanine transferase, U/L^?/sup>

9

48

Alkaline phosphatase, U/L^¥

132

1090

Parathyroid hormone, pg/ml^Ω

N/A

72

Voriconazole level, trough, max/normalization, mg/L®

N/A

7.7/4.3

Fluoride level, peak/normalization^∞, umol/L

24.6/5.8

28.3/UD