Lung Volume Subdivisions

GOLD Stage

P-value†

1

(n = 98)

2

(n = 150)

3

(n = 60)

4

(n = 23)

FVC, liters

3.8 ± 0.9

3.1 ± 0.9

2.3 ± 0.7

1.9 ± 0.7

<0.001

FVC, % pred

104.2 ± 12.6

84.8 ± 14.6

64.9 ± 14.3

48.1 ± 16.8

<0.001

SVC, liters

3.9 ± 1.0

3.2 ± 0.8

2.6 ± 0.8

2.3 ± 0.6

<0.001

SVC, % pred

106.5 ± 14.6

87.6 ± 14.2

71.5 ± 16.1

55.8 ± 14.1

<0.001

FEV1, liters

2.5 ± 0.6

1.7 ± 0.5

1.1 ± 0.3

0.7 ± 0.2

<0.001

FEV1, % pred

93.5 ± 10.6

65.7 ± 8.6

39.6 ± 5.7

22.9 ± 5

<0.001

FEV1/FVC

0.65 ± 0.04

0.58 ± 0.08

0.45 ± 0.11

0.35 ± 0.13

<0.001

TLC, liters

6.2 ± 1.3

5.8 ± 1.3

5.8 ± 1.7

6.6 ± 2.1

0.04

TLC, % pred

111.2 ± 17.1

104.4 ± 18.9

105.8 ± 23.4

106.9 ± 28.6

0.07

FRC, liters

3.5 ± 0.8

3.5 ± 0.9

3.9 ± 1.3

5.3 ± 1.8

<0.001

FRC, % pred

113.3 ± 26.3

115.0 ± 25.7

131.4 ± 35.4

153.6 ± 44.7

<0.001

RV, liters

2.3 ± 0.7

2.7 ± 0.8

3.2 ± 1.2

4.4 ± 1.6

<0.001

RV, % pred

122.4 ± 38.3

141.8 ± 39.8

172.3 ± 54.9

221.2 ± 70.9

<0.001

IC, liters

2.7 ± 0.8

2.3 ± 0.6

1.8 ± 0.6

1.3 ± 0.4

<0.001

IC, % pred

107.9 ± 21.3

92.4 ± 18.1

73.9 ± 18.6

48.5 ± 13.1

<0.001

IC/SVC

0.70 ± 0.11

0.74 ± 0.13

0.72 ± 0.11

0.60 ± 0.14

0.002

IC/TLC

0.43 ± 0.07

0.39 ± 0.07

0.31 ± 0.07

0.20 ± 0.04

<0.001

FRC/TLC

0.57 ± 0.07

0.61 ± 0.07

0.69 ± 0.07

0.80 ± 0.04

<0.001

RV/TLC

0.38 ± 0.09

0.46 ± 0.09

0.57 ± 0.08

0.67 ± 0.06

<0.001

SVC/FVC

1.01 ± 0.07

1.01 ± 0.09

1.06 ± 0.11

1.02 ± 0.13

<0.001