Author, Year

Type of Surgery

Method of Mg administration

Rate of Mg infusion

Intraoperative (I) or

Postoperative (P)

# of Subjects

(#Mg/#Control)

Control

Cumulative |Morphine Consumption within first 24 hours (Magnesium group) (mg)

Cumulative Morphine Consumption with first 24 hours (Control group) (mg)

Wilder- Smith, 1997 [35]

Abdominal hysterectomy

Bolus + continuous

infusion

200 mg/h

I, P

13/11

Placebo

41.8 ± 9.6

46.8 ± 14.1

Zarauza, 2000 [36]

Colorectal surgery

Bolus + continuous infusion

10 mg/kg/h

I, P

23/24

Placebo and saline

39.8 ± 9.2

46.6 ± 11.3

Kara, 2002 [37]

Abdominal hysterectomy

Bolus + continuous infusion

500 mg/h

I, P

12/12

Saline

35.55 ± 0.48

43.43 ± 7.2

Levaux, 2003 [38]

Orthopedic surgery

Continuous infusion

50 mg/kg/ 30 mins

I

12/12

Saline

42.37 ± 17.75

68.8 ± 26.51

Bhatia, 2004 [39]

Open cholecystectomy

Bolus + continuous

infusion

10 mg/kg/h

I

25/25

Saline

13.7 ± 3

15.2 ± 2.7

Seyhan, 2006 (1) [40]

Abdominal

hysterectomy

Bolus

40 mg/kg/h

I, P

20/20

Saline

42.2 ± 16.4

64 ± 10.2

Seyhan, 2006 (2) [40]

Abdominal hysterectomy

Bolus +

continuous infusion

10 mg/kg/h

I, P

20/20

Saline

39.2 ± 15.5

64 ± 10.2

Seyhan, 2006 (3) [40]

Abdominal hysterectomy

Bolus +

continuous infusion

20 mg/kg/h

I, P

20/20

Saline

39.16 ± 15.51

64 ± 10.2

Tauzin-fin, 2006 [41]

Prostatectomy

Continuous infusion

16.7 mg/kg/h

I

15/15

Saline

226 ± 60

444 ± 73

Ozcan, 2007 [42]

Thoracotomy

Bolus + continuous infusion

10 mg/kg/h

P

12/12

Saline

22.2 ± 3.8

23.5 ± 4.6

O-mentes, 2008 [43]

Laparoscopic cholecystectomy

Continuous infusion only

n/a

I

41/42

Saline

12 ± 6.4

23 ± 11.5

Ferasatkish, 2008 [44]

Coronary artery bypass surgery

Continuous infusion only

32 nmol/kg/h

I

109/109

Saline

13.6 ± 2.8

20.1 ± 3.5

Oguzhan, 2008 [45]

Lumbar disc surgery

Continuous infusion only

10 mg/kg/h

I

25/25

Saline

56.27 ± 18.16

63.49 ± 25.92

Kaya, 2009 [46]

Abdominal hysterectomy

Bolus +

continuous infusion

500 mg/h

I

20/20

Saline

30.2 ± 10.2

36.7 ± 7.3

Dabbagh, 2009 [47]

Lower limb surgery

Continuous infusion only

8 mg/kg/h

I

30/30

Saline

4.2 ± 1.6

9.8 ± 1.2

Saadawy, 2010 [48]

Laparoscopic

cholecystectomy

Bolus + continuous infusion

25 mg/kg/h

I

40/40

Saline

16.1 ± 8.6

27.2 ± 9.3

Kumar, 2013 [20]

Below umbilical surgeries

Bolus + continuous infusion

10 mg/kg/h

I

30/30

Saline

3.99 ± 1.25

7.13 ± 2.68