Response groups

Responsive

Partially responsive

Non- responsive

Interval p-value

Interval p-value

Interval p-value

Changes in creatinine clearance:

Time 0:

102 ± 6

94 ± 5

94 ± 6

<0.001

<0.001

NS

Time 3 M:

92 ± 7

86 ± 5

86 ± 7

NS

<0.001

<0.02

Time 12 M:

102 ± 5

87 ± 7

73 ± 10

<0.01

NS

<0.008

Time 24 M:

104 ± 4

93 ± 7

77 ± 7

Final p-value (0 - 24):

NS

NS

0.008

Changes in protein output:

Time 0:

8870 (2723)

5730 (630)

5820

<0.001

<0.43

NS

Time 3 M:

370 (258)

1560 (640)

4200

NS

NS

NS

Time 12 M:

360 (223)

1820 (610)

3900

NS

NS

NS

Time 24 M:

380 (220)

1900 (600)

4200

Final p-value (0 - 24):

<0.001

<0.043

NS