| Induction therapy |
| DOSE | Comments |
| Methylprednisolone then prednisolone | IV PO | MP 500 - 750 mg × 3 consecutive days then prednisone 1 mg/kg/day not exceeding 75 mg; tapered after a few weeks to lowest effective dose | Usually 3 - 6 months |
|
| Plus |
| |
| Cyclophosphamide-First Option | IV | Refer Table 2, 6 - 12 infusions, 3 - 6 months | |
| Rituximab-Second Option | IV | 375 mg/m2 × 4 doses | Cannot tolerate or not responding to IV Cyclophosphamide |
|
| Plus |
|
|
| Plasma Exchange |
| 7 exchanges in 2 weeks | Pulmonary Haemorrhage and or severe renal insufficiency |
| Maintenance Therapy | Plus |
|
|
| Prednisolone | PO | tapering dose-till 5 - 7 mg/daily | Usually 18 months since remission |
| Azathioprine-First Option | PO | 1 - 3 mg/kg/day | |
| MMF Second Option | PO | 1 - 1.5 gm twice daily | |
| MPS-Second Option | PO | 720 - 1080 mg twice daily |