Patient

Age and sex

History

Clinical presentation

Hemogram

Hemoglobin electrophoresis

Complications

No. 1

49 years old, F

· Freshwater swimming

· 1^st degree consanguinity

· Brothers who died of abdominal pain

· Long history of abdominal pain

· Splenomegaly

· Abdominal pain

· Anemic syndrome

Anemia (7.6 g/dL)

HbC: 99.2%; HbA2: 0.8%

Gallbladder lithiasis

No. 2

22 years old, F

· 2 miscarriages

· Long history of hemolytic anemia

· 2^nd degree consanguinity

· Clinical Anemia

· Subictere

· Splenomegaly

· Progressive pregnancy (25SA)

Anemia (11 g/dL)

HbC: 95.3%; HbA2: 4.7%

Normal delivery

No. 3

27 years old, M

· Abdominal pain since childhood

· 2^nd degree consanguinity

Abdominal sensitivity

Hb: 12.1 g/dL

HbC: 94.6% and HbA2:5.4%.

Good clinical evolution