GSAS

Questions

ARM-A

ARM-B

ARM-C

Baseline Visit

End of Study Visit

P-Value

Baseline Visit

End of Study Visit

P-Value

Baseline Visit

End of Study Visit

P-Value

Heart burn or burning

pain in Chest region

2.04 (0.19)

0.66 (0.48)

<0.0001

2.05 (0.21)

0.65 (0.48)

<0.0001

2.07 (0.25)

0.65 (0.48)

<0.0001

Chest Pressure or

Discomfort

2.25 (0.55)

0.66 (0.47)

<0.0001

2.23 (0.54)

0.66 (0.47)

<0.0001

2.30 (0.54)

0.66 (0.48)

<0.0001

Food coming back

into the mouth

2.07 (0.55)

0.74 (0.44)

<0.0001

2.08 (0.57)

0.74 (0.44)

<0.0001

2.08 (0.49)

0.74 (0.44)

<0.0001

Acidic or Sour Taste

in mouth

2.02 (0.34)

0.68 (0.46)

<0.0001

2.02 (0.34)

0.66 (0.48)

<0.0001

2.04 (0.31)

0.62 (0.49)

<0.0001

Frequent Stomach

Gurgling

2.30 (0.54)

0.68 (0.46)

<0.0001

2.29 (0.53)

0.68 (0.47)

<0.0001

2.41 (0.59)

0.61 (0.49)

<0.0001

Pressure Or Lump in

the Throat

2.13 (0.62)

0.63 (0.48)

<0.0001

2.09 (0.63)

0.61 (0.49)

<0.0001

2.22 (0.67)

0.59 (0.49)

<0.0001

Nausea

1.84 (0.37)

0.62 (0.49)

<0.0001

1.82 (0.39)

0.59 (0.49)

<0.0001

1.92 (0.27)

0.61 (0.49)

<0.0001

Burning throat Pain

1.94 (0.23)

0.70 (0.46)

<0.0001

1.94 (0.24)

0.74 (0.44)

<0.0001

1.97 (0.16)

0.73 (0.45)

<0.0001

Bloating

1.98 (0.58)

0.76 (0.43)

<0.0001

1.96 (0.59)

0.73 (0.44)

<0.0001

2.14 (0.51)

0.81 (0.39)

<0.0001

Belching

2.04 (0.60)

0.79 (0.41)

<0.0001

2.02 (0.62)

0.77 (0.42)

<0.0001

2.09 (0.55)

0.78 (0.41)

<0.0001

Flatulence

2.07 (0.56)

0.76 (0.43)

<0.0001

2.03 (0.55)

0.76 (0.43)

<0.0001

2.09 (0.53)

0.82 (0.38)

<0.0001

Early satiety

1.98 (0.40)

0.70 (0.46)

<0.0001

1.99 (0.40)

0.71 (0.45)

<0.0001

1.99 (0.39)

0.78 (0.41)

<0.0001

Halitosis

1.85 (0.42)

0.71 (0.45)

<0.0001

1.87 (0.41)

0.74 (0.44)

<0.0001

1.88 (0.37)

0.76 (0.43)

<0.0001

Cough

1.86 (0.35)

0.56 (0.50)

<0.0001

1.85 (0.36)

0.58 (0.49)

<0.0001

1.88 (0.33)

0.59 (0.49)

<0.0001

Hoarseness

1.89 (0.31)

0.08 (0.27)

<0.0001

1.89 (0.31)

0.08 (0.28)

<0.0001

1.95 (0.23)

0.08 (0.27)

<0.0001

GSAS Score

2.02 (0.23)

0.23 (0.42)

<0.0001

2.01 (0.23)

0.24 (0.43)

<0.0001

2.07 (0.20)

0.26 (0.44)

<0.0001