Author

Defect number

Healing time (months)

Groups

PPD reduction/change

(mm)

CAL gain

(mm)

P value

Patel, et al. 2017 [2]

26

(bilateral)

12

OFD alone

PRF + OFD

2.4 ± 0.69

4.2 ± 1.32

2.1 ± 0.46

3.60 ± 0.04

PPD < 0.001

CAL < 0.001

Pham, et al. 2021 [1]

90

12

OFD + PRF

GTR

OFD alone

4.80 ± 0.71

4.63 ± 0.67

3.37 ± 1.00

5.00 ± 0.46

4.53 ± 0.57

3.37 ± 1.22

PPD < 0.001

CAL < 0.001

Csifo, et al. 2021 [3]

30

6

A-PRF

EMD

4.67 ± 0.62 4.67 ± 0.62

2.33 ± 1.58 2.60 ± 1.18

PPD < 0.001

CAL < 0.001

Lui, et al. 2021 [4]

28

At 12 and 24

GTR + BPBM + PRF

GTR + BPBM

NA

Buccal: 3.1 ± 0.5

Lingual: 3.1 ± 0.7

Buccal: 2.1 ± 1.1

Lingual:

2.0 ± 0.8

P < 0.05

P < 0.05

Charttejee, et al. 2017 [5]

90

9

OFD

OFD + PRF

OFD + TPRF

3.68 ± 0.72

5.46 ± 1.04

6.25 ± 1.11

4.14 ± 0.76

6.57 ± 1.47

6.74 ± 1.55

PPD < 0.001

CAL < 0.001