B

SE

t value

p

PRO-INFLAMMATORY

Log CRP (mg/L)

Intent-to-treat analysis (ITT)

0.001

0.002

0.66

0.511

Per-protocol analysis (PP)

0.001

0.002

0.47

0.642

Log TNF-α (pg/ml)

ITT

0.000

0.001

0.18

0.857

PP

0.000

0.001

0.78

0.438

Log IL-1β (pg/ml)

ITT

0.001

0.002

0.59

0.556

PP

0.001

0.003

0.37

0.713

Log IFN-γ (pg/ml)

ITT

0.004

0.002

2.42

0.017

PP

0.005

0.002

2.28

0.024

Log IL-6 (pg/ml)

ITT

0.001

0.002

0.35

0.725

PP

0.000

0.002

0.23

0.820

IL-12 p70 (pg/ml)

ITT

0.021

0.011

1.96

0.052

PP

0.007

0.008

0.90

0.369

ANTI-INFLAMMATORY

Log IL-1ra (pg/ml)

ITT

0.003

0.003

1.15

0.252

PP

0.002

0.004

0.62

0.539

IL-4 (pg/ml)

ITT

0.027

0.040

0.67

0.502

PP

0.017

0.042

0.39

0.694

Log IL-10 (pg/ml)

ITT

0.001

0.003

0.54

0.593

PP

0.000

0.003

−0.13

0.899

STRESS HORMONES

Log Cortisol (mg/L creatinine)

ITT

0.001

0.001

1.83

0.069

PP

0.002

0.001

1.77

0.079

Log Epinephrine (mg/L creatinine)

ITT

0.000

0.001

0.24

0.808

PP

0.001

0.000

0.69

0.490

Log Norepinephrine (mg/L creatinine)

ITT

0.000

0.001

0.15

0.880

PP

0.000

0.001

−0.11

0.914