| IL-10 (pg/ml) | |||||
| Intention-to-treat analysis | |||||
| Baseline (63 vs. 59) | 9.43 (8.85) | 9.09 (12.56) | 0.34 (−3.59 to 4.26) | 0.101 | |
| 12-week (43 vs. 42) | 8.05 (9.13) | 5.74 (8.10) | 2.31 (−1.41 to 6.04) | 0.016 | |
| 24-week (28 vs. 27) | 6.23 (5.34) | 4.91 (8.62) | 1.32 (−2.59 to 5.24) | 0.012 | |
| Per-protocol analysis | |||||
| Baseline (45 vs. 43) | 8.71 (8.73) | 7.70 (11.18) | 1.01 (−3.23 to 5.25) | 0.209 | |
| 12-week (40 vs. 38) | 8.12 (9.42) | 6.13 (8.41) | 1.99 (−2.05 to 6.03) | 0.038 | |
| 24-week (26 vs. 24) | 6.16 (5.49) | 5.29 (9.09) | 0.87 (−3.47 to 5.22) | 0.023 | |
| STRESS HORMONES | |||||
| Cortisol (mg/L creatinine) | |||||
| Intention-to-treat analysis | |||||
| Baseline (62 vs. 62) | 35.50 (19.56) | 32.70 (17.45) | 2.80 (−3.79 to 9.39) | 0.379 | |
| 12 weeks (46 vs. 42) | 31.15 (19.63) | 30.56 (18.42) | 0.59 (−7.50 to 8.68) | 0.937 | |
| 24 weeks (28 vs. 27) | 23.19 (9.09) | 28.60 (27.36) | −5.41 (−16.70 to 5.88) | 0.959 | |
| Per-protocol analysis | |||||
| Baseline (43 vs. 46) | 35.90 (20.62) | 31.43 (17.07) | 4.47 (−3.49 to 12.42) | 0.293 | |
| 12 weeks (44 vs. 38) | 30.41 (19.07) | 31.24 (18.87) | −0.83 (−9.19 to 7.54) | 0.821 | |
| 24 weeks (26 vs. 23) | 23.99 ( 8.94) | 30.66 (29.16) | −6.67 (−19.68 to 6.35) | 0.986 | |
| Epinephrine (mg/L creatinine) | |||||
| Intention-to-treat analysis | |||||
| Baseline (62 vs. 63) | 12.22 (20.95) | 10.29 (17.57) | 1.93 (−4.89 to 8.75) | 0.576 | |
| 12 weeks (44 vs. 43) | 5.73 (5.55) | 5.28 (4.22) | 0.45 (−1.65 to 2.56) | 0.779 | |
| 24 weeks (30 vs. 27) | 5.55 (4.49) | 3.67 (3.15) | 1.88 (−0.20 to 3.96) | 0.067 | |
| Per-protocol analysis | |||||
| Baseline (46 vs. 46) | 12.58 (22.24) | 10.86 (19.92) | 1.72 (−7.03 to 10.46) | 0.87 | |
| 12 weeks (42 vs. 39) | 5.75 (5.66) | 5.13 (4.06) | 0.63 (−1.55 to 2.79) | 0.273 | |
| 24 weeks (28 vs. 23) | 5.35 (4.23) | 3.90 (3.17) | 1.45 (−0.69 to 3.60) | 0.098 | |
| Norepinephrine (mg/L creatinine) |
| ||||
| Intention-to-treat analysis | |||||
| Baseline (61 vs. 62) | 52.20 (42.08) | 50.08 (28.79) | 2.12 (−10.79 to 15.03) | 0.85 | |
| 12 weeks (46 vs. 41) | 60.85 (44.05) | 52.01 (35.07) | 8.83 (−8.28 to 25.95) | 0.748 | |
| 24 weeks (30 vs. 27) | 52.04 (35.50) | 43.87 (34.52) | 8.17 (−10.46 to 26.80) | 0.198 | |
| Per-protocol analysis | |||||
| Baseline (44 vs. 45) | 56.44 (47.59) | 53.29 (31.47) | 3.15 (−13.93 to 20.23) | 0.715 | |
| 12 weeks (44 vs. 37) | 61.49 (44.64) | 51.31 (32.35) | 10.18 (−7.36 to 27.73) | 0.76 | |
| 24 weeks (28 vs. 23) | 53.93 (35.94) | 45.11 (35.42) | 8.81 (−11.38 to 29.01) | 0.197 | |