IL-6 (pg/ml)

Intention-to-treat analysis

Baseline (64 vs. 62)

2.84 (2.57)

2.56 (2.49)

0.28 (−0.61 to 1.17)

0.900

12-week (45 vs. 41)

2.40 (1.78)

2.13 (1.45)

0.27 (−0.43 to 0.97)

0.997

24-week (29 vs. 26)

2.03 (2.06)

2.00 (1.87)

0.03 (−1.04 to 1.10)

0.413

Per-protocol analysis

Baseline (45 vs. 44)

2.23 (2.06)

2.19 (2.20)

0.04 (−0.85 to 0.94)

0.820

12-week (42 vs. 37)

2.36 (1.79)

2.12 (1.49)

0.24 (−0.50 to 0.99)

0.978

24-week (27 vs. 23)

2.05 (2.12)

1.96 (1.99)

0.09 (−1.09 to 1.26)

0.505

IL-12 p70 (pg/ml)

Intention-to-treat analysis

Baseline (64 vs. 62)

2.99 (2.28)

2.95 (3.85)

0.04 (−1.08 to 1.16)

0.946

12-week (43 vs. 41)

2.54 (1.96)

2.24 (1.52)

0.30 (−0.47 to 1.06)

0.439

24-week (29 vs. 27)

1.99 (1.30)

1.85 (1.33)

0.14 (−0.56 to 0.85)

0.682

Per-protocol analysis

Baseline (45 vs. 44)

2.50 (1.98)

2.46 (2.20)

0.04 (−0.84 to 0.92)

0.928

12-week (40 vs. 37)

2.45 (1.83)

2.31 (1.55)

0.14 (−0.63 to 0.91)

0.719

24-week (27 vs. 24)

2.03 (1.32)

1.81 (1.41)

0.22 (−0.54 to 0.99)

0.563

ANTI-INFLAMMATORY

IL-1ra (pg/ml)

Intention-to-treat analysis

Baseline (64 vs. 63)

33.78 (70.89)

39.10 (71.71)

−5.32 (−30.36 to 19.73)

0.630

12-week (46 vs. 41)

25.65 (40.57)

21.43 (35.93)

4.22 (−12.20 to 20.65)

0.098

24-week (30 vs. 24)

23.43 (27.18)

47.52 (76.74)

−24.09 (−57.77 to 9.58)

0.474

Per-protocol analysis

Baseline (46 vs. 46)

23.62 (38.27)

48.42 (81.50)

−24.80 (−51.32 to 1.72)

0.974

12-week (43 vs. 38)

26.52 (41.75)

22.21 (37.22)

4.30 (−13.29 to 21.89)

0.09

24-week (28 vs. 22)

24.63 (27.74)

51.16 (79.27)

−26.53 (−26.53 to 62.96)

0.440

IL-4 (pg/ml)

Intention-to-treat analysis

Baseline (63 vs. 58)

12.72 (12.72)

12.33 (11.89)

0.38 (−4.06 to 4.83)

0.865

12-week (43 vs. 43)

9.95 ( 8.46)

11.07 (11.25)

−1.12 (−5.39 to 3.15)

0.605

24-week (28 vs. 27)

6.77 ( 6.46)

7.15 (10.42)

−0.39 (−5.12 to 4.35)

0.870

Per-protocol analysis

Baseline (45 vs. 43)

11.47 (10.34)

11.51 (11.92)

−0.04 (−4.76 to 4.68)

0.986

12-week (40 vs. 39)

9.53 (8.42)

11.75 (11.55)

−2.22 (−6.74 to 2.30)

0.437

24-week (26 vs. 24)

6.73 (6.67)

7.84 (10.86)

−1.10 (−6.31 to 4.11)

0.671