Differences

Glycine (native amino acid)

Arginine (mutant amino acid)

Schematic structure

Size

Small in size

Bigger in size

Charge

Natural in charge

Positively charge and it could make repulsion between the mutant residue and neighboring residues

Flexibility

Most flexible of all residues

Can abolish this function which it might be necessary for the protein’s function

Conservation

Highly conserved

Not observed at all, this mean

in just some rare cases the mutation might occur without damaging the protein