Case subject

Biomarker

CP-II

CS846

HA

COMP

MMP-3

TIMP-1

11 y ♀

Baseline

139.35

47.99

286.20

16.58

3.11

3.30

12^th week

547.79

53.11

406.09

20.80

2.57

3.57

∆ (ng/ml)

+408.44

+5.12

+119.89

+4.22

−0.54

+0.27

9 y ♀

Baseline

576.67

44.06

334.61

13.41

1.33

13.41

12^th week

712.28

46.54

193.09

15.37

1.26

132.57

∆ (ng/ml)

+135.61

+2.48

−141.52

+1.96

−0.07

+119.16

8 y ♂

Baseline

493.95

53.59

136.53

13.26

1.44

not detectable

12^th week

1326.6

59.35

413.96

15.97

1.17

9.68

∆ (ng/ml)

+832.65

+5.76

+277.43

+2.71

−0.27

-