Compounds

Antiadipogenesis

MTT

IUPAC Name

R₁

R₂

R₃

R₄

R₅

IC₅₀ ± SEM^a

IC₅₀ ± SEM^a

7-Hydroxy-8-methyl-2H-chromen-2-

one (8)

CH₃

OH

H

H

H

48.59 ± 0.03

NA^¥

3-Acetyl-8-methoxy-2H-chromen-2-one (9)

OCH₃

H

H

H

COCH₃

39.54 ± 0.03

NA^¥

Ethyl-6,8-dichloro-2-oxo-2H-chromen-

3-carboxylate (10)

Cl

H

Cl

H

COOC₂H₅

37.79 ± 0.03

NA^¥

7-Hydroxy-4-methyl-2H-chromen-2-one (11)

H

OH

H

CH₃

H

26.46 ± 0.03

NA^¥

7-Ethoxy-4-methyl-2H-chromen-2-one

(12)

H

OC₂H₅

H

CH₃

H

8.0 ± 0.03

NA^¥

3-Acetyl-2H-chromen-2-one (13)

H

H

H

H

COCH₃

62.12 ± 0. 3

NA^¥

2-Oxo-2H-chromen-3-carboxamide

(14)

H

H

H

H

CONH₂

29.61 ± 0.015

NA^¥

6-Bromo-2-oxo-2H-chromen-3- carboxamide (15)

H

H

Br

H

CONH₂

53.15 ± 0.03

NA^¥

8-Methoxy-2-oxo-2H-chromen-3- carboxamide (16)

OCH₃

H

H

H

CONH₂

92.10 ± 0.03

NA^¥

8-Ethoxy-2-oxo-2H-chromen-3- carboxamide (17)

OC₂H₅

H

H

H

CONH₂

>100

>30

8-Ethoxy-3(4-nitrophenyl)-2H- chromen-2-one (18)

OC₂H₅

H

H

H

Ph-NO₂

>100

>30

Ethyl-8-methoxy-2-oxo-2H-chromen-3- carboxylate (19)

OCH₃

H

H

H

COOC₂H₅

>100

NA^¥

3-Acetyl-8-ethoxy-2-oxo-2H-chromen-2 -one(20)

OC₂H₅

H

H

H

COCH₃

50.0 ± 0.01

NA^¥

Ethyl-8-ethoxy-2-oxo-2H-chromen-3- carboxylate (21)

OC₂H₅

H

H

H

COOC₂H₅

44.38 ± 0.04

NA^¥

6-Methoxy-2-oxo-2H-chromen-3- carboxamide (22)

H

H

OCH₃

H

CONH₂

62.87 ± 0.02

NA^¥

6-Methoxy-3(4-nitrophenyl)-2H- chromen-2-one (23)

H

H

OCH₃

H

Ph-NO₂

>100

>30

3-Acetyl-6-methoxy-2H-chromen-2-one (24)

H

H

OCH₃

H

COCH₃

46.32 ± 0.02

NA^¥