Cause of Death

Analysis

Group

Urinary creatinine-adjusted NNAL, ng/g-cr

Estimated Hazard Ratio (95% Confidence Interval)

BLLOD

[LLOD, 2.0)

[2.0, 200)

[200, 400)

400+

All-cause

Adjusted

Full Sample

1.000

(ref)

0.867

(0.580, 1.297)

1.320

(0.969, 1.798)

2.426***

(1.711, 3.440)

2.799***

(2.045, 3.830)

Unadjusted

Full Sample

1.000

(ref)

0.959

(0.640, 1.437)

1.692**

(1.251, 2.289)

3.190***

(2.251, 4.519)

3.604***

(2.683, 4.841)

Current Smokers

1.000

(ref)

1.210

(0.743, 1.971)

1.336

(0.832, 2.147)

Former Smokers

1.000

(ref)

0.909

(0.534, 1.547)

1.898**

(1.323, 2.723)

Never Smokers

1.000

(ref)

1.036

(0.602, 1.783)

1.220

(0.760, 1.958)

Cancer

Adjusted

Full Sample

1.000

(ref)

0.795

(0.468, 1.349)

0.994

(0.615, 1.605)

2.046*

(1.147, 3.648)

3.387***

(2.018, 5.683)

Unadjusted

Full Sample

1.000

(ref)

0.847

(0.498, 1.441)

1.182

(0.744, 1.879)

2.585**

(1.427, 4.685)

4.083***

(2.591, 6.437)

Current Smokers

1.000

(ref)

1.212

(0.487, 3.019)

2.002

(0.929, 4.317)

Former Smokers

1.000

(ref)

0.971

(0.439, 2.149)

1.781

(0.857, 3.700)

Never Smokers

1.000

(ref)

0.769

(0.363, 1.629)

0.513

(0.236, 1.116)

CVD

Adjusted

Full Sample

1.000

(ref)

1.639

(0.624, 4.304)

1.425

(0.656, 3.098)

3.381**

(1.361, 8.398)

3.438**

(1.466, 8.062)

Unadjusted

Full Sample

1.000

(ref)

1.936

(0.760, 4.932)

2.081*

(1.042, 4.156)

4.954**

(1.968, 12.470)

4.768***

(2.351, 9.671)

Current Smokers

1.000

(ref)

2.210

(0.822, 5.945)

2.163

(0.780, 5.998)

Former Smokers

1.000

(ref)

1.491

(0.471, 4.722)

1.291

(0.558, 2.985)

Never Smokers

1.000

(ref)

2.816

(0.727, 10.907)

3.519

(0.966, 12.817)

Other- causes

Adjusted

Full Sample

1.000

(ref)

0.732

(0.371, 1.445)

1.479

(0.928, 2.357)

2.405**

(1.488, 3.888)

2.331**

(1.493, 3.641)

Unadjusted

Full Sample

1.000

(ref)

0.814

(0.412, 1.609)

1.925**

(1.226, 3.021)

3.186***

(1.959, 5.181)

3.043***

(1.993, 4.646)

Current Smokers

1.000

(ref)

1.069

(0.617, 1.851)

0.930

(0.461, 1.873)

Former Smokers

1.000

(ref)

0.675

(0.253, 1.805)

2.145**

(1.281, 3.590)

Never Smokers

1.000

(ref)

0.976

(0.406, 2.345)

1.422

(0.799, 2.531)