Inclusion criteria

Exclusion criteria

1) Patients who met the criteria of TB diagnosis and treatment guidelines made by TB Branch of Chinese Medical Association [39] ;

1) Patients with severe liver and kidney disease history;

2) Mtb strains from them were sensitive to INH + RIF + EMB according to pre-treatment drug susceptibility testing;

2) Mental illness, gout and diabetes history;

3) Alanine aminotransferase (ALT) ≤ 3 times upper limit of normal (ULN);

3) HIV antibody positive, long-term use of immunosuppressive agents, severe malnutrition;

4) Total bilirubin ≤ 2.5 times ULN;

4) Currently enrolled in or was going to start medications of antiretroviral and/or immunosuppressive agents in next 8 weeks.

5) Creatinine ≤ 2 times ULN;

5) Discontinuation of treatment due to serious adverse effects;

6) Hemoglobin ≥ 7.0 g/dL;

6) Failure to complete the six-month treatment program;

7) Platelets ≥ 100,000/mm³;

7) Pregnancy or breast-feeding;

8) Non-pregnant;

8) Weight < 40 kg;

9) ≤5 days of anti-tuberculosis treatment in last 6 months.

9) Central nervous system tuberculosis;

10) Pulmonary silicosis.