ADMET Descriptor | Level | Description |
ADMET Absorption Level (Human Intestinal Absorption (HIA)) | 0 | Good absorption |
1 | Moderate absorption | |
2 | Low absorption | |
3 | Very low absorption | |
ADMET Solubility Level (Aqueous Solubility Levels) | 0 | Extremely low |
1 | No, very low, but possible | |
2 | Yes, low | |
3 | Yes, good | |
4 | Yes, optimal | |
5 | No, too soluble | |
6 | Warning: molecules with one or more unknown AlogP98 types | |
ADMET Blood Brain Barrier (BBB Penetration Levels) | 0 | Very High |
1 | High | |
2 | Medium | |
3 | Low | |
4 | Undefined | |
5 | Warning: molecules with one or more unknown AlogP98 types | |
ADMET Cytochrome P450 2D6 (CYP2D6) Inhibition | 0 | Non-inhibitor |
1 | Inhibitor | |
ADMET Hepatotoxicity | 0 | Non-hepatotoxic |
1 | Toxic | |
ADMET PPB (Plasma Protein Binding) | 0 | Binding is <90% |
1 | Binding is ≥90% | |
AMES Mutagenicity | 0 | Non-mutagen |
1 | Mutagen |