ADMET Descriptor

Level

Description

ADMET Absorption Level (Human Intestinal Absorption (HIA))

0

Good absorption

1

Moderate absorption

2

Low absorption

3

Very low absorption

ADMET Solubility Level (Aqueous Solubility Levels)

0

Extremely low

1

No, very low, but possible

2

Yes, low

3

Yes, good

4

Yes, optimal

5

No, too soluble

6

Warning: molecules with one or more unknown AlogP98 types

ADMET Blood Brain Barrier (BBB Penetration Levels)

0

Very High

1

High

2

Medium

3

Low

4

Undefined

5

Warning: molecules with one or more unknown AlogP98 types

ADMET Cytochrome P450 2D6 (CYP2D6) Inhibition

0

Non-inhibitor

1

Inhibitor

ADMET Hepatotoxicity

0

Non-hepatotoxic

1

Toxic

ADMET PPB (Plasma Protein Binding)

0

Binding is <90%

1

Binding is ≥90%

AMES Mutagenicity

0

Non-mutagen

1

Mutagen