Cancer | In Vitro/In Vivo /Ex Vivo | Model/cell | Mechanism/Results | References |
Anaplastic thyroid cancer | In Vitro and In Vivo | 8505c, SW1736 | ↓Proliferation ↓Metastatic ability ↓Angiogenesis and metastasis Emodin exerts anti-angiogenic and anti-metastatic activities in ATC by affecting TRAF6 mediated pathways. | [25] |
Breast cancer | In Vitro | MDA-MB-231 MDA-MB-453 | Proliferation ↓Metastasis Emodin inhibits adipocyte secretion of CCL5, inhibits the EMT of TNBC cells, and inhibits tumor growth and lung and liver metastasis, suggesting that emodin has a new role in the prevention of TNBC metastasis. | [22] |
Lung cancer | In Vitro | A549 | ↓Viability ↓Proliferation Emodin regulates the cell cycle of non-small cell lung cancer cells through a HAS2-HACD44/RHAMM interaction-dependent signaling pathway. | [33] |
Lung cancer | In Vitro and In Vivo | HL-60N1 | ↑ROS, ↓autophagy, induced apoptosis Emodin selectively inhibits N2 neutrophils, thereby preventing hypercoagulability and the development of lung cancer. | [34] |
lung cancer | In Vitro | A549 H1299 | ↓Viability ↑Apoptosis The TRIB3 signal is associated with emodin-induced endoplasmic reticulum stress-mediated apoptosis of lung cancer cells | [19] |
lung cancer | In Vitro | A549 | ↓Proliferation ↓Viability ↓Migration Emodin inhibits ATP-induced proliferation, migration, and EMT by inhibiting P2Y receptor mediated [Ca2+]I increase and NF-κB signaling in A549 cells. | [32] |
Hepatocellular carcinoma | In Vitro | HepG2 | ↓Viability ↓Proliferation ↓Growth 859 DEGs and 5 HUB genes were identified, which may be regarded as the target of emodin therapy for HCC. | [20] |
Hepatocellular carcinoma | In Vitro | Bel-7402 | ↓Proliferation ↑Apoptosis ↓Viability Emodin can induce apoptosis of hepatocellular carcinoma cells in SREBP 1-dependent and SREBP 1-independent ways. | [26] |
Hepatocellular carcinoma | In Vitro | HepG2 | ↑Apoptosis Emodin induces apoptosis by up-regulation of CypD | [37] |
Hepatocellular carcinoma | In Vitro | SMMC-7721 | ↑Apoptosis ↓Proliferation Emodin may be a potentially effective and safe drug to induce apoptosis in HCC cells | [38] |
Colon cancer | In Vitro | HCT116 SW480 SNU-C2ASNU-C5 | ↓Proliferation Emodin provides a molecular basis for the treatment of colon cancer by inhibiting FASN-mediated cell growth and apoptosis. | [40] |