S/N

Nation

Treatment group

Sample size

Dosage/

Intervention

Treatment

Duration

Timing of vitamin D intervention

Results

Reference

1

Europe

Vitamin D

Placebo

70

70

50,000 IU/2 weeks

10 weeks

14 - 16

No association found between vitamin D supplementation and developing GDM.

[79]

2

Iran

Vitamin D

Placebo

46

45

5000 Units/week

Until the 26th week

First trimester

Incidence of GDM in intervention group was statistically lower than in control group (P < 0.001)

[53]

3

Iran

Vitamin D3

Placebo

36

36

50,000 IU/2 weeks

10 months

24 - 28 weeks

Vitamin D supplements were associated with a significant decrease in fasting glucose (P = 0.01) and HbA1c (P = 0.02).

[54]

4

China

Calciferol

Low dose

Medium dose

High dose

Placebo

38

38

37

20

200 IU/daily

2000 IU/daily

4000 IU/daily

Until the delivery

25 days

12.5 days

24 - 28 weeks

High and medium doses of vitamin D supplementation reduces

Insulin and HOMA‑IR levels in mothers with GDM (P < 0.01).

[55]

5

Australia

Vitamin D3

High dose

Low dose

Nonrandomized

89

90

24

5000 IU/daily

400 IU/daily

Until the delivery (from <20 weeks)

<20 weeks

No association found between vitamin D supplementation and developing GDM.

[80]

6

Iran

Vitamin D3

Placebo

27

27

50,000 IU twice (at baseline & day 21)

6 weeks

24 - 28 weeks

Vitamin D supplementation significantly decreases concentrations of FPG (P < 0.001), serum insulin (P = 0.01) & HOMA-IR (P < 0.001).

[56]

7

China

Plain yogurt with vitamin D3

Plain yogurt without vitamin D3

52

51

Two servings (200 g) of supplemented

yogurt per day (500 IU vitamin D3 per serving)

16 weeks

13 weeks

Vitamin D supplements statistically reduce FPG (P = 0.04), serum insulin (0.03) & HOMA-IR (P = 0.01).

[57]