| Confirmation of diagnosis | Treatment | Confirmation of recurrence | Confirmation of response to PBT | Molecular profiling | ||||||
| Pathology | Radiology | |||||||||
| Patient | Place and date | Diagnosis | Place and date | Diagnosis | Place and date | Assessment | Place and date | Assessment | ||
| 1 | University hospital April 28, 2010 | GBM | Regional radiology MRI April 26, 2010 | Two enhancing masses in left parietal and temporal lobes | Subtotal tumor resection April 27, 2010 |
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| RT + TMZ May 20, 2010 to July 1, 2010 |
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| TMZ ×2 August 21, 2010 to September 21, 2010 | Regional radiology MRI September 21, 2010 | Recurrence |
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| BC. October 6, 2010 PB, vorinostat, erlotinib, pazopanib, everolimus, BVZ. Discontinued vorinostat on December 15, 2010 and had last BVZ infusion on December 12, 2010. Discontinued erlotinib, everolimus, and pazopanib January 18, 2011. Recurrence of rectal abscess. Discontinued PB on March 1, 2011.Died March 1, 2011 due to septicemia. |
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| Regional radiology MRI November 30, 2010 | PR | Elevated VEGF (Blood) c-Kit-wild type genotype (tissue-Caris) |
| 2 | Regional hospital December 2010 | GBM | Regional radiology CT November 25, 2010 | A large 5.5 × 4 cm lesion of the left temporal parietal lobe | Tumor resection December 2, 2010 |
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| RT and TMZ |
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| Craniotomy for epidural abscess | Regional radiology MRI November 10, 2011 (Baseline) | Persistent tumor |
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| TMZ ×4 |
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| BC. November 30, 2011 PB, pazopanib, dasatinib, sirolimus, erlotinib, BVZ |
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| Regional radiology MRI May 17, 2012 | SD | Blood and tissue profiling not done |
| 3 | Regional hospital September 1, 2011 | GBM | Regional hospital MRI August 25, 2011 | Left parietal lobe enhancing tumor | Tumor resection August 31, 2011 |
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| RT 60 Gy and TMZ October 10, 2011- November 18, 2011 |
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| TMZ | Regional radiology MRI March 14, 2012 | Recurrence |
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| BVZ March 2012 to December 28, 2012 | Regional hospital MRI December 12, 2012.
Regional radiology MRI January 9, 2013. | Recurrence
Recurrence
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| BC. January 15, 2013 PB, pazopanib, everolimus, dasatinib, BVZ. Discontinued everolimus February 13, 2013 (lack of insurance). Added erlotinib April 16, 2013. Discontinued erlotinib May 21, 2013. Discontinued PB March 3, 2014. Died June 23, 2014 due to disease progression. |
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| Regional radiology MRI March 20, 2013 | PD | Normal (blood) FGFR3-amplification, PTEN-mutation U1331, CDK4-amplification, TP53-loss, mutation D281H (tissue) |