Author, years

Study design

No. of subject

Age of patients (years)

No. of patients completed dose

Efficacy

Safety

Tolerability/ acceptability

Need of enema

Diet

Adamiak et al., 2010 [17]

Retrospective, 1 arm: PEG-3350, 238 or 255 g in 1.9 L of sport drink within 2 hours

272

13.7^a, (1.08 - 17.92)^b

NA

Cecum reached 97.4%, procedure cancelled 1.1%

NA

NA

19/253

Regular meal for breakfast and lunch the day before the colonoscopy and clear liquids up to 3 hrs prior to their schedule

Abbas et al., 2013 [19]

Prospective, open label trial: PEG-3350, 238 g with 1.5 L Gatorade in a few hours

46

14.50 ± 2.9^c

(8 - 18)^b

43/46

Cecum reached 100%, terminal ileum 84%; BBPS 6.16^d and BPPS score of least 5 in 33 (77%)

Nausea/ vomiting 60%, abdominal pain/ cramping 44%, fatigue/ weakness 40%, call on call provider 11%;

K⁺, BUN, CO₂ statistically decreased^#

Likert scale acceptable (3) 64%, palatable (≥3) 73%, volume (≤2) 62%, unacceptable (≤2) 31%

2/46

Clear liquid after 1200 hrs the day before

Walia et al., 2013 [20]

Prospective, 1 arm: PEG-3350 without electrolyte,

<45 kg 136 g mixed in 32 ounces of Gatorade

>45 kg 255 g mixed in 64 ounces of Gatorade

45

14 ± 3^c, (7 - 20)^b

40/45

Terminal ileum 100%; ^*excellent 23%, good 52%, fair 23%, poor 21%

Nausea 34%, abdominal pain 23%, vomiting 16%, abdominal distension 20%, bloating 23%, dizziness 7%; serum glucose and CO₂ significantly decrease^#

^*Tolerability 39% or easy 61%, palatable good 14%, Ok 75%, bad 9%, yucky 2%

NA

Clear liquid the day before and NPO 3 hrs prior procedure

Najafi et al., 2014 [22]

Randomised control trial, 2 arm:

PEG, 2 g/kg (17 g in 240 ml of water or another beverage with 5 mg bisacodyl BD × 1 day

PEG-3350, 1.5 g/kg with fruit juice for 2 days with 5 mg bisacodyl BD × 2 days

100

6.9 ± 31^c vs 8 ± 3^c

(2 - 14)^b

46/50 vs 47/50

Boston score excellent 7 vs 7, good 28 vs 29, fair 11 vs 11, poor 4 vs 3

^{^}Nausea 1 vs 3, bloating 1 vs 1, abdominal pain 2 vs 4, headache 1 vs 2

^*Full easy and tasty 20 vs 28, easy and tasty 26 vs 20, some tasteless and hard 3 vs 2, tasteless and hard 1 vs 0

^{^}no significantly difference

^{^}6/50 vs 9/50

Fruit juice were allowed