Mcdonaled criteria for assessment of progression in glioma

Complete response

Requires all of the following: complete disappearance of all enhancing measurable and non measurable disease sustained for at least 4 weeks; no new lesions; no corticosteroids; and stable or improved clinically

Partial response

Requires all of the following: 50% decrease compared with baseline in the sum of) products of perpendicular diameters of all measurable enhancing lesions sustained for at least 4 weeks; no new lesions; stable or reduced corticosteroid dose; and stable or Improved clinically

Stable disease

Requires all of the following: does not qualify for complete response, partial response, or progression; and stable clinically

Progression

Defined by any of the following: 25% increase in sum of the products of perpendicular diameters of enhancing lesions; any new lesion; or clinical deterioration