Dose level

Dose mg/m2/d

Comments

Reduce TMZ by 1 dose level if:

Stop TMZ

−1

100

Reduction for prior toxicity

ANC < 1 (×109/L)

if dose < 100 mg/m² is required or if the same Grade 3 NH toxicity recurred after dose reduction or became G4

0

150

Dose during cycle 1

Plat < 50 (×109/L)

1

200

Cycles 2 - 6 (if no toxicity)

NH toxicity G3