No prophylactic therapy

Prophylactic therapy (lamivudine)

Prophylactic therapy (entecavir)

P-value

Histology

B-NHL

42

52

52

ECOG

0 or 1

41

50

48

0.15

>1

1

2

4

Chemotherapy regimen

CHOP

42

49

52

0.33

Hyper CVAD

0

3

2

Normal baseline ALT

38

52

52

0.61

No. of patients HBV DNA monitored

42

52

52

Incidence of hepatitis (Total)

22 (52.4%)

12 (23.1%)

2 (3.85%)

P = 0.000a1

P = 0.006a2

P = 0.000a3

P = 0.01a4

HBV-reactivation

21(50.0%)

10(19.2%)

1(1.92%)

P = 0.000a1

P = 0.001a2

P = 0.000a3

P = 0.013a4

Interrupt of planned chemotherapy

7(16.7%)

2(3.85%)

0(0%)