Compound | R | IC50 ± SDa | |
AChE (nM) | BACE 1 (µM) | ||
1b |
| 634.3 ± 32.5 | 174.82 ± 8.93 |
1c |
| 528.9 ± 27.6 | 130.08 ± 7.5 |
1d |
| 433.7 ± 24.7 | 73.2 ± 3.32 |
1f |
| 462.6 ± 27.3 | 78.75 ± 3.74 |
1g |
| 375.4 ± 21.8 | 131.46 ± 8.73 |
2b |
| 248.31 ± 14.42 | 68.79 ± 3.84 |
2c |
| 238.23 ± 13.91 | 60.59 ± 5.73 |
2d |
| 211.84 ± 13.59 | 37.96 ± 2.31 |
2e |
| 323.59 ± 18.18 | 40.72 ± 2.73 |
2f |
| 263.03 ± 16.15 | 28.22 ± 1.64 |
2g |
| 246.04 ± 14.3 | 35.06 ± 2.53 |
2j |
| 223.87 ± 13.19 | 22.24 ± 2.16 |
2k |
| 357.27 ± 19.86 | 21.46 ± 1.26 |
3b |
| 74.44 ± 5.72 | 47.18 ± 3.58 |
3c |
| 65.6 ± 4.28 | 5.87 ± 0.34 |
3d |
| 25.48 ± 1.85 | 4.45 ± 0.32 |
3f |
| 81.65 ± 9.1 | 2.96 ± 0.27 |
3g |
| 76.56 ± 5.63 | 8.49 ± 0.56 |
3h |
| 81.85 ± 4.13 | 1.69 ± 0.09 |