Doses

75

150

300

600

1200

Average sample size/% Stop. Trials

Prob. True Toxicity

0.06

0.08

0.14

0.20

0.30

Prob. True Activity

0.20

0.40

0.60

0.80

0.55

BDTM: % allocation

20.5

3.6

30.1

18.6

7.2

N = 25

BDTM: % selection

0.5

9.6

37.2

33.1

14.5

5.1

BDEM + BDTM: % allocation

22.6

19.9

39.4

18.1

0

N = 24

BDEM + BDTM: % selection

0.2

1.2

54.4

44.1

0.1

0